L-Ergothioneine

Elevate well-being with ErgoActive®, the ergothioneine with benefits shown through rigorous clinical research and made by precision fermentation. Harness the power of science to support a longevity lifestyle.

Blue California’s flagship ingredient, ErgoActive® ergothioneine, is a cutting-edge longevity ingredient that may support mitochondrial, cellular and whole-body health.
Clinically supported, continued investment into science: double-blinded randomized placebo-controlled studies, with ongoing  studies at top academic research institutions.
Award Recognition: Finalist position for the prestigious Nutra-Ingredients USA 2025 Award for our commitment to supporting quality science.
Ease of formulation: water-soluble with neutral taste and exceptional stability.
Advanced Technology: with our proprietary precision fermentation technologies to produce nature-identical bio-based ergothioneine.
Safety: first bio-based ergothioneine to achieve FDA-reviewed GRAS (#734) in 2019; clinically studied to support safety.
What is L-Ergothioneine?
L-Ergothioneine is a next-generation antioxidant with growing recognition as a “longevity vitamin.” This unique amino acid is naturally found in mushrooms and fermented foods, but must be obtained through diet or supplementation. What makes ergothioneine stand out?

Unmatched stability: Unlike other antioxidants, ergothioneine resists degradation, even under heat or oxidative stress.
Targeted delivery: It’s actively transported into cells and mitochondria via the body’s own ergothioneine transporter (OCTN1/ETT).
Long retention: Unlike typical water-soluble nutrients, it stays in the body longer, making it ideal for sustained protection.
Ergothioneine helps defend against oxidative stress, supports mitochondrial health, and plays a growing role in healthy aging.